ASSOCIATION RULE MINING FOR PREDICTION OF COVID-19

COVID-19 is a raging pandemic that has created havoc with its impact ranging from loss of millions of human lives to social and economic disruptions of the entire world. Therefore, error-free prediction, quick diagnosis, disease identification, isolation and treatment of a COVID patient have become extremely important. Nowadays, mining knowledge and providing scientific decision making for diagnosis of diseases from clinical datasets has found wide-ranging applications in healthcare sector. In this direction, among different data mining tools, association rule mining has already emerged out as a popular technique to extract invaluable information and develop important knowledge-base to help in intelligent diagnosis of distinct diseases quickly and automatically. In this paper, based on 5434 records of COVID cases collected from a popular data science community and using Rapid Miner Studio software, an attempt is put forward to develop a predictive model based on frequent pattern growth algorithm of association rule mining to determine the likelihood of COVID-19 in a patient. It identifies breathing problem, fever, dry cough, sore throat, abroad travel and attended large gathering as the main indicators of COVID-19. Employing the same clinical dataset, a linear regression model is also proposed having a moderately high coefficient of determination of 0.739 in accurately predicting the occurrence of COVID-19. A decision support system can also be developed using the association rules to ease out and automate early detection of other diseases. © 2023 by the authors.

COVID-19 Bed Management Using a Two-Step Process Mining and Discrete-Event Simulation Approach

The sudden admission of many patients with similar needs caused by the COVID-19 (SARS-CoV-2) pandemic forced health care centers to temporarily transform units to respond to the crisis. This process greatly impacted the daily activities of the hospitals. In this paper, we propose a two-step approach based on process mining and discrete-event simulation for sizing a recovery unit dedicated to COVID-19 patients inside a hospital. A decision aid framework is proposed to help hospital managers make crucial decisions, such as hospitalization cancellation and resource sizing, taking into account all units of the hospital. Three sources of patients are considered: (i) planned admissions, (ii) emergent admissions representing day-to-day activities, and (iii) COVID-19 admissions. Hospitalization pathways have been modeled using process mining based on synthetic medico-administrative data, and a generic model of bed transfers between units is proposed as a basis to evaluate the impact of those moves using discrete-event simulation. A practical case study in collaboration with a local hospital is presented to assess the robustness of the approach. Note to Practitioners—In this paper we develop and test a new decision-aid tool dedicated to bed management, taking into account exceptional hospitalization pathways such as COVID-19 patients. The tool enables the creation of a dedicated COVID-19 intensive care unit with specific management rules that are fine-tuned by considering the characteristics of the pandemic. Health practitioners can automatically use medico-administrative data extracted from the information system of the hospital to feed the model. Two execution modes are proposed: (i) fine-tuning of the staffed beds assignment policies through a design of experiment and (ii) simulation of user-defined scenarios. A practical case study in collaboration with a local hospital is presented. The results show that our model was able to find the strategy to minimize the number of transfers and the number of cancellations while maximizing the number of COVID-19 patients taken into care was to transfer beds to the COVID-19 ICU in batches of 12 and to cancel appointed patients using ICU when the department hit a 90% occupation rate. IEEE

Rapid protocols to support COVID-19 clinical diagnosis based on hematological parameters

Purpose: In December 2019, the Covid-19 pandemic began in the world. To reduce mortality, in addiction to mass vaccination, it is necessary to massify and accelerate clinical diagnosis, as well as creating new ways of monitoring patients that can help in the construction of specific treatments for the disease. Objective: In this work, we propose rapid protocols for clinical diagnosis of COVID-19 through the automatic analysis of hematological parameters using evolutionary computing and machine learning. These hematological parameters are obtained from blood tests common in clinical practice. Method: We investigated the best classifier architectures. Then, we applied the particle swarm optimization algorithm (PSO) to select the most relevant attributes: serum glucose, troponin, partial thromboplastin time, ferritin, D-dimer, lactic dehydrogenase, and indirect bilirubin. Then, we assessed again the best classifier architectures, but now using the reduced set of features. Finally, we used decision trees to build four rapid protocols for Covid-19 clinical diagnosis by assessing the impact of each selected feature. The proposed system was used to support clinical diagnosis and assessment of disease severity in patients admitted to intensive and semi-intensive care units as a case study in the city of Paudalho, Brazil. Results: We developed a web system for Covid-19 diagnosis support. Using a 100-tree random forest, we obtained results for accuracy, sensitivity, and specificity superior to 99%. After feature selection, results were similar. The four empirical clinical protocols returned accuracies, sensitivities and specificities superior to 98%. Conclusion: By using a reduced set of hematological parameters common in clinical practice, it was possible to achieve results of accuracy, sensitivity, and specificity comparable to those obtained with RT-PCR. It was also possible to automatically generate clinical decision protocols, allowing relatively accurate clinical diagnosis even without the aid of the web decision support system. © 2023, The Author(s), under exclusive licence to The Brazilian Society of Biomedical Engineering.

AI and Dynamic Prediction of Deterioration in Covid-19

During the COVID-19 pandemic it became evident that outcome prediction of patients is crucial for triaging, when resources are limited and enable early start or increase of available therapeutic support. COVID-19 demographic risk factors for severe disease and death were rapidly established, including age and sex. Common Clinical Decision Support Systems (CDSS) and Early Warning Systems (EWS) have been used to triage based on demographics, vital signs and laboratory results. However, all of these have limitations, such as dependency of laboratory investigations or set threshold values, were derived from more or less specific cohort studies. Instead, individual illness dynamics and patterns of recovery might be essential characteristics in understanding the critical course of illness.The pandemic has been a game changer for data, and the concept of real-time massive health data has emerged as one of the important tools in battling the pandemic. We here describe the advantages and limitations of established risk scoring systems and show how artificial intelligence applied on dynamic vital parameter changes, may help to predict critical illness, adverse events and death in patients hospitalized with COVID-19.Machine learning assisted dynamic analysis can improve and give patient-specific prediction in Clinical Decision Support systems that have the potential of reducing both morbidity and mortality. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022.

Hybrid manufacturing-remanufacturing system of essential commodity in the context of COVID-19

PurposeThis paper aims to assess the feasibility of a hybrid manufacturing and remanufacturing system (HMRS) for essential commodities in the context of COVID-19. Specifically, it emphasises using HMRS based on costs associated with various manufacturing activities.Design/methodology/approachThe combination of mathematical model and system dynamics is used to model the HMRS system. The model was tried on sanitiser bottle manufacturing to generalise the result.FindingsThe remanufacturing cost is higher because of reverse logistics, inspection and holding costs. Ultimately remanufacturing costs turn out to be lesser than the original manufacturing the moment system attains stability.Practical implicationsThe study put forth the reason to encourage remanufacturing towards sustainability through government incentives.Originality/valueThe study put forth the feasibility of the HMRS system for an essential commodity in the context of a covid pandemic. The research implemented system dynamics for modelling and validation.

Harnessing Machine Learning in Early COVID-19 Detection and Prognosis: A Comprehensive Systematic Review.

During the early phase of the COVID-19 pandemic, reverse transcriptase-polymerase chain reaction (RT-PCR) testing faced limitations, prompting the exploration of machine learning (ML) alternatives for diagnosis and prognosis. Providing a comprehensive appraisal of such decision support systems and their use in COVID-19 management can aid the medical community in making informed decisions during the risk assessment of their patients, especially in low-resource settings. Therefore, the objective of this study was to systematically review the studies that predicted the diagnosis of COVID-19 or the severity of the disease using ML. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA), we conducted a literature search of MEDLINE (OVID), Scopus, EMBASE, and IEEE Xplore from January 1 to June 31, 2020. The outcomes were COVID-19 diagnosis or prognostic measures such as death, need for mechanical ventilation, admission, and acute respiratory distress syndrome. We included peer-reviewed observational studies, clinical trials, research letters, case series, and reports. We extracted data about the study's country, setting, sample size, data source, dataset, diagnostic or prognostic outcomes, prediction measures, type of ML model, and measures of diagnostic accuracy. Bias was assessed using the Prediction model Risk Of Bias ASsessment Tool (PROBAST). This study was registered in the International Prospective Register of Systematic Reviews (PROSPERO), with the number CRD42020197109. The final records included for data extraction were 66. Forty-three (64%) studies used secondary data. The majority of studies were from Chinese authors (30%). Most of the literature (79%) relied on chest imaging for prediction, while the remainder used various laboratory indicators, including hematological, biochemical, and immunological markers. Thirteen studies explored predicting COVID-19 severity, while the rest predicted diagnosis. Seventy percent of the articles used deep learning models, while 30% used traditional ML algorithms. Most studies reported high sensitivity, specificity, and accuracy for the ML models (exceeding 90%). The overall concern about the risk of bias was "unclear" in 56% of the studies. This was mainly due to concerns about selection bias. ML may help identify COVID-19 patients in the early phase of the pandemic, particularly in the context of chest imaging. Although these studies reflect that these ML models exhibit high accuracy, the novelty of these models and the biases in dataset selection make using them as a replacement for the clinicians' cognitive decision-making questionable. Continued research is needed to enhance the robustness and reliability of ML systems in COVID-19 diagnosis and prognosis.

Scheduling Model for a Trigeneration System With Energy Storage Unit: A Hospital Application

Over the last three COVID-19 effective years, it was evident that healthcare has been the most sensitive sector to electricity failures. Therefore, if well developed and implemented, a microgrid system with an integrated energy storage system (ESS) installed in hospitals has great potential to provide an uninterrupted and low-energy cost solution. In this article, we target to show the importance of the installed ESS against the problems that will arise from power outages and energy quality problems in hospitals. Besides, it aims to construct an energy management system (EMS) based on the scheduling model to meet the lowest cost of a system containing solar panels, microturbine, gas boiler, and energy storage units that are repurposed lithium-ion batteries from electric vehicles and thermal storage tank. EMS is a mixed-integer linear program to meet the hospital's electricity, heating, and cooling demands with the lowest cost for every hour. The established scheduling model is run for a hospital in Antioch, Turkiye, with 197 beds, 4 operating rooms, 2 resuscitation units, and 9 intensive care units for every hour based on the data in 2019. With the EMS, approximately 25% savings were achieved compared to the previous energy cost. Furthermore, as the result of the net present value calculation, the payback period of the proposed system is estimated to be approximately seven years.

Logistics for Diagnostic Testing: an Adaptive Decision-support Framework

Diagnostic testing is a fundamental component in effective outbreak containment during every phase of a pandemic. Test samples are collected at testing facilities and subsequently analyzed at specialized laboratories. In high-income countries where health care providers are often privately owned, the assignments of samples from testing facilities to laboratories are determined by individual stakeholders. While this decentralized system effectively matches supply and demand during normal times, dispersed outbreaks, e.g., as encountered during the COVID-19 pandemic, lead to imbalanced requests for diagnostic capacity. With no coordinating entity in place to match demands at testing facilities to laboratory capacities, local backlogs build up rapidly thus increasing waiting times for test results and thus impeding subsequent containment efforts. To ease the impact of erratic regional outbreaks through improved logistics activities, we develop a rolling horizon framework which repeatedly solves a mathematical programming snapshot problem based on the current number of test samples. The procedure dynamically adapts to requirements resulting from the pandemic activity and supports rather than replaces decentralized operations in order to match testing requests with available laboratory capacities. We present problem-specific performance indicators and assess the quality of our procedure in a case study based on the COVID-19 outbreak in 2020 in Germany. Experimental results demonstrate the potential of coordinating mechanisms to support the logistics related to diagnostic testing and hence to reduce waiting times for PCR test results. Significant improvements are achieved even when interventions in the decentralized assignment process only occur in response to increased pandemic activity.

Exploring the topic structure and evolutionary trends of health informatics research in library and information science

PurposeThis study aims to reveal the topic structure and evolutionary trends of health informatics research in library and information science.Design/methodology/approachUsing publications in Web of Science core collection, this study combines informetrics and content analysis to reveal the topic structure and evolutionary trends of health informatics research in library and information science. The analyses are conducted by Pajek, VOSviewer and Gephi.FindingsThe health informatics research in library and information science can be divided into five subcommunities: health information needs and seeking behavior, application of bibliometrics in medicine, health information literacy, health information in social media and electronic health records. Research on health information literacy and health information in social media is the core of research. Most topics had a clear and continuous evolutionary venation. In the future, health information literacy and health information in social media will tend to be the mainstream. There is room for systematic development of research on health information needs and seeking behavior.Originality/valueTo the best of the authors' knowledge, this is the first study to analyze the topic structure and evolutionary trends of health informatics research based on the perspective of library and information science. This study helps identify the concerns and contributions of library and information science to health informatics research and provides compelling evidence for researchers to understand the current state of research.

PDSS: A Pharmacological Decision Support System for Diabetics Patients with COVID-19.

With the advent of SARS-CoV-2, several studies have shown that there is a higher mortality rate in patients with diabetes and, in some cases, it is one of the side effects of overcoming the disease. However, there is no clinical decision support tool or specific treatment protocols for these patients. To tackle this issue, in this paper we present a Pharmacological Decision Support System (PDSS) providing intelligent decision support for COVID-19 diabetic patient treatment selection, based on an analysis of risk factors with data from electronic medical records using Cox regression. The goal of the system is to create real world evidence including the ability to continuously learn to improve clinical practice and outcomes of diabetic patients with COVID-19.

An intelligent platform of services based on multimedia understanding and telehealth for supporting the management of SARS-CoV-2 multi-pathological patients

The combination of pervasive sensing and multimedia understanding with the advances in communications makes it possible to conceive platforms of services for providing telehealth solutions responding to the current needs of society. The recent outbreak has indeed posed several concerns on the management of patients at home, urging to devise complex pathways to address the Severe Acute Respiratory Syndrome (SARS) in combination with the usual diseases of an increasingly elder population. In this paper, we present TiAssisto, a project aiming to design, develop, and validate an innovative and intelligent platform of services, having as its main objective to assist both Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) multi-pathological patients and healthcare professionals. This is achieved by researching and validating new methods to improve their lives and reduce avoidable hospitalisations. TiAssisto features telehealth and telemedicine solutions to enable high-quality standards treatments based on Information and Communication Technologies (ICT), Artificial Intelligence (AI) and Machine Learning (ML). Three hundred patients are involved in our study: one half using our telehealth platform, while the other half participate as a control group for a correct validation. The developed AI models and the Decision Support System assist General Practitioners (GPs) and other healthcare professionals in order to help them in their diagnosis, by providing suggestions and pointing out possible presence or absence of signs that can be related to pathologies. Deep learning techniques are also used to detect the absence or presence of specific signs in lung ultrasound images. © 2022 IEEE.

Artificial Intelligence Assisted Decision Making in Predicting COVID-19 Patient's Path

Artificial Intelligence (AI) has made significant advances in all aspects of healthcare. Different studies have been investigated using AI regarding improve patient diagnosis, emergency care, and patient safety for different diseases. The coronavirus disease (COVID-19) has escalated into a global public health emergency. Different have shown clinical decisions for COVID-19 on diagnosis accuracy, severity risk, and so on. Moreover, few studies have focussed on clinical decisions for COVID-19. The fact global pandemic of corona poses a big challenge for clinicians, this research intends to detect a coronavirus patient path based on the virus' biological traits and presents an adequate mechanism for the efficient decision support system that assists doctors in predicting a COVID-19 patient. To train and test our model, we used 311 patient data which are 214 (69%) male and 96 (31%) female. Data were collected and maintained from three centers of Ethiopian Hospitals from Nov 2021 to March 2022 with the age range of 21 up to 67. The experiments were performed with three Machine Learning (ML) algorithms, namely Naïve Bayes (NB), Artificial Neural Network (ANN), and Support Vector Machine (SVM). The model was validated using input variables (n=10) which achieved better involvement in the virus symptoms identification and based on the evaluation metrics, ANN achieved 97%, 96%, 85%, and 98.3% for recall, precision, and F1- measures respectively. Our results demonstrated that the SVM algorithm achieved a 91.3% average accuracy and the other two methods had 87.75% and 96.05% respectively. In this research, ANN does better than the NB classifier by 8.3% on average and better than SVM by 4.75%. In addition, using more prediction algorithms and a larger dataset includes more parameters used to estimate patients. [ FROM AUTHOR] Copyright of Journal of Pharmaceutical Negative Results is the property of ResearchTrentz and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)

Deep Metric Learning for Transparent Classification of Covid-19 X-Ray Images

This work proposes an interpretable classifier for automatic Covid-19 classification using chest X-ray images. It is based on a deep learning model, in particular, a triplet network, devoted to finding an effective image embedding. Such embedding is a non-linear projection of the images into a space of reduced dimension, where homogeneity and separation of the classes measured by a predefined metric are improved. A K-Nearest Neighbor classifier is the interpretable model used for the final classification. Results on public datasets show that the proposed methodology can reach comparable results with state of the art in terms of accuracy, with the advantage of providing interpretability to the classification, a characteristic which can be very useful in the medical domain, e.g. in a decision support system. © 2022 IEEE.

A Hybrid Algorithm of ML and XAI to Prevent Breast Cancer: A Strategy to Support Decision Making.

Worldwide, the coronavirus has intensified the management problems of health services, significantly harming patients. Some of the most affected processes have been cancer patients' prevention, diagnosis, and treatment. Breast cancer is the most affected, with more than 20 million cases and at least 10 million deaths by 2020. Various studies have been carried out to support the management of this disease globally. This paper presents a decision support strategy for health teams based on machine learning (ML) tools and explainability algorithms (XAI). The main methodological contributions are: first, the evaluation of different ML algorithms that allow classifying patients with and without cancer from the available dataset; and second, an ML methodology mixed with an XAI algorithm, which makes it possible to predict the disease and interpret the variables and how they affect the health of patients. The results show that first, the XGBoost Algorithm has a better predictive capacity, with an accuracy of 0.813 for the train data and 0.81 for the test data; and second, with the SHAP algorithm, it is possible to know the relevant variables and their level of significance in the prediction, and to quantify the impact on the clinical condition of the patients, which will allow health teams to offer early and personalized alerts for each patient.

AAPM task group report 273: Recommendations on best practices for AI and machine learning for computer-aided diagnosis in medical imaging.

Rapid advances in artificial intelligence (AI) and machine learning, and specifically in deep learning (DL) techniques, have enabled broad application of these methods in health care. The promise of the DL approach has spurred further interest in computer-aided diagnosis (CAD) development and applications using both "traditional" machine learning methods and newer DL-based methods. We use the term CAD-AI to refer to this expanded clinical decision support environment that uses traditional and DL-based AI methods. Numerous studies have been published to date on the development of machine learning tools for computer-aided, or AI-assisted, clinical tasks. However, most of these machine learning models are not ready for clinical deployment. It is of paramount importance to ensure that a clinical decision support tool undergoes proper training and rigorous validation of its generalizability and robustness before adoption for patient care in the clinic. To address these important issues, the American Association of Physicists in Medicine (AAPM) Computer-Aided Image Analysis Subcommittee (CADSC) is charged, in part, to develop recommendations on practices and standards for the development and performance assessment of computer-aided decision support systems. The committee has previously published two opinion papers on the evaluation of CAD systems and issues associated with user training and quality assurance of these systems in the clinic. With machine learning techniques continuing to evolve and CAD applications expanding to new stages of the patient care process, the current task group report considers the broader issues common to the development of most, if not all, CAD-AI applications and their translation from the bench to the clinic. The goal is to bring attention to the proper training and validation of machine learning algorithms that may improve their generalizability and reliability and accelerate the adoption of CAD-AI systems for clinical decision support.

PiMS: A Pre-ML Labelling Tool

Machine Learning (ML) techniques in clinical decision support systems are scarce due to the limited availability of clinically validated and labelled training data sets. We present a framework to (1) enable quality controls at data submission toward ML appropriate data, (2) provide in-situ algorithm assessments, and (3) prepare dataframes for ML training and robust stochastic analysis. We developed and evaluated PiMS (Pandemic Intervention and Monitoring Systems): a remote monitoring solution for patients that are Covid-positive. The system was trialled at two hospitals in Melbourne, Australia (Alfred Health and Monash Health) involving 109 patients and 15 clinicians.

A Decision Support System Based on Machine Learning to Counteract Covid-Like Pandemic Events

In this paper, the authors aim to design a decision support system (DSS) based on machine learning (ML) to assist institutions in implementing targeted countermeasures to combat and prevent emergencies such as the COVID -19 pandemic. The DSS relies on an ensemble of several ML models that combine heterogeneous data to predict risk levels at the micro and macro levels. Some preliminary analyses have already been conducted showing the correlation between nitrogen dioxide (NO2), mobility-related parameters, and COVID -19 data. However, given the complexity of the virus spread mechanism, which is related to many different factors, these preliminary studies confirmed the need to perform more in-depth analyses on the one hand and to use ML algorithms on the other hand to capture the hidden relationships between the huge amounts of data that need to be processed.

A Review of the Application of Artificial Intelligence in Medicine: From Data to Personalised Models

Artificial intelligence leverages sophisticated computation and inference to generate insights, enables the system to reason and learn, and empowers decision making of clinicians. Starting from data (medical images, biomarkers, patients' data) and using powerful tools such as convolutional neural networks, classification, and regression models etc., it aims at creating personalized models, adapted to each patient, which can be applied in real clinical practice as a decision support system to doctors. This chapter discusses the use of AI in medicine, with an emphasis on the classification of patients with carotid artery disease, evaluation of patient conditions with familiar cardiomyopathy, and COVID-19 models (personalized and epidemiological). The chapter also discusses model integration into a cloud-based platform to deal with model testing without any special software needs. Although AI has great potential in the medical field, the sociological and ethical complexity of these applications necessitates additional analysis, evidence of their medical efficacy, economic worth, and the creation of multidisciplinary methods for their wider deployment in clinical practice. © 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.

Preprocessing and Artificial Intelligence for Increasing Explainability in Mental Health

This paper shows the added value of using the existing specific domain knowledge to generate new derivated variables to complement a target dataset and the benefits of including these new variables into further data analysis methods. The main contribution of the paper is to propose a methodology to generate these new variables as a part of preprocessing, under a double approach: creating 2nd generation knowledge-driven variables, catching the experts criteria used for reasoning on the field or 3rd generation data-driven indicators, these created by clustering original variables. And Data Mining and Artificial Intelligence techniques like Clustering or Traffic light Panels help to obtain successful results. Some results of the project INSESS-COVID19 are presented, basic descriptive analysis gives simple results that even though they are useful to support basic policy-making, especially in health, a much richer global perspective is acquired after including derivated variables. When 2nd generation variables are available and can be introduced in the method for creating 3rd generation data, added value is obtained from both basic analysis and building new data-driven indicators. © 2023 World Scientific Publishing Company.